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<!--Generated by Squarespace Site Server v5.11.5 (http://www.squarespace.com/) on Sat, 31 Jul 2010 07:27:19 GMT--><feed xmlns="http://www.w3.org/2005/Atom" xmlns:dc="http://purl.org/dc/elements/1.1/"><title>Home</title><subtitle>Home</subtitle><id>http://blog.locustwalkpartners.com/frontpage/</id><link rel="alternate" type="application/xhtml+xml" href="http://blog.locustwalkpartners.com/frontpage/"/><link rel="self" type="application/atom+xml" href="http://blog.locustwalkpartners.com/frontpage/atom.xml"/><updated>2010-03-24T20:50:50Z</updated><generator uri="http://www.squarespace.com/" version="Squarespace Site Server v5.11.5 (http://www.squarespace.com/)">Squarespace</generator><entry><title>Out of Whack: Biotech Business Development Compensation</title><category term="BD compensation"/><category term="banker vs CBO"/><category term="biotech business develompent"/><id>http://blog.locustwalkpartners.com/frontpage/2010/3/24/out-of-whack-biotech-business-development-compensation.html</id><link rel="alternate" type="text/html" href="http://blog.locustwalkpartners.com/frontpage/2010/3/24/out-of-whack-biotech-business-development-compensation.html"/><author><name>Geoff Meyerson</name></author><published>2010-03-24T20:41:02Z</published><updated>2010-03-24T20:41:02Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>Biotech business development is out of whack!&nbsp; Something needs to be done fast or the best, brightest, and most experienced will leave their companies.&nbsp; Below is an example of what is wrong with biotech BD and what can be done to fix it.</p>
<p>Suppose senior investment bankers get paid a small base, say $200K, and a bonus usually with an extra zero on it.&nbsp; Biotech Chief Business Officers (CBO) likely receive anywhere from $200-300K in base salary and possibly 25% in bonus compensation with a ~2% equity kicker vested over 4 years (not counting re-vesting for re-greening).&nbsp; How can two people who both are arguably transaction professionals doing largely the same thing (yes I know there are differences) get paid in such radically different ways?</p>
<p>Three questions that you should think about:</p>
<ul>
<li>Which person is more financially motivated based on these structures?</li>
<li>Who does more deals? and</li>
<li>Which person has more variability in compensation?</li>
</ul>
<p>Answers:</p>
<ul>
<li>Banker</li>
<li>Banker</li>
<li>CBO (yes it&rsquo;s true, I&rsquo;ll get to it in a second)</li>
</ul>
<p>A senior banker is basically paid a percentage of revenue, which is directly related to closing deals.&nbsp; He/she might work on 10-20 deals a year and close 2 or 3 if not more.&nbsp; Let&rsquo;s say the average success fee is $5M.&nbsp; That&rsquo;s $10-15M in revenue, of which maybe 10% gets paid out to the lead banker equating to $1-1.5M.&nbsp; The $200K base plus $1-1.5M in bonus is $1.2-1.7M in annual compensation.</p>
<p>The CBO gets his/her $250-350K in cash compensation including bonus and depending on the type of company, might be involved in one deal every year or every other year (they might not do any deals if the technology fails or they company needs more data).&nbsp; What if, though, that deal is not an exit, and there are no more deals to be done at the company?&nbsp; It doesn&rsquo;t make sense to stick around anymore waiting for the equity to vest and hoping for an M&amp;A.&nbsp; Let&rsquo;s say this BD deal happens two years into your four year vesting cycle.&nbsp; The CBO only earned 1% of the company and hasn&rsquo;t realized any value from that equity.&nbsp; He/she now has to make a decision whether or not to buy those shares, not knowing if they will ever be worth anything (for private companies only).&nbsp; How many biotech companies exit for large sums?&nbsp; In 2009, 19 private venture backed companies exited out of thousands potentially for sale.&nbsp; A BD exec would be lucky to get one good one in a career.&nbsp; Two is like getting hit by lightening.&nbsp; A typical &ldquo;homerun&rdquo; of $300M x 2% = $6M if you&rsquo;re there at exit and assuming all VC preferences have been washed away.&nbsp; $300M x 1% is $3M, but more often than not, you will be heavily diluted after leaving the company and after they raise more capital.&nbsp; Your 1% might end up as 0.5% or 0.25%.&nbsp; On a $300M exit that is worth $1.5M or $0.75K.&nbsp; That equates to $750K or $375K in &ldquo;bonus&rdquo; per year.&nbsp; What if you only have one of those in a 20 year career?&nbsp; Many companies don&rsquo;t ever get a deal or an exit.&nbsp; That is &lt;$100K in &ldquo;bonus&rdquo; per year and is highly variable.&nbsp; Bankers&rsquo; bonuses have much lower variability (much higher risk adjusted value) compared to M&amp;A exists for biotech BD execs.</p>
<p>What does all of this math mean?&nbsp; Bankers have a much better deal financially and one of three things needs to happen:</p>
<ul>
<li>Biotech companies with one or two products need to hire bank (who need to learn how to do business develpoment, not just M&amp;A)</li>
<li>They need to hire Locust Walk Partners (sorry for the self serving commercial), or most likely</li>
<li>They need to compensate their business development professionally in a radically different way to properly incent these professionals financially.</li>
</ul>
<p>Equity options in a company and success fees that could be paid for a transaction can and often have little correlation in economic value, especially in private companies.&nbsp; I suspect that if this paradigm doesn&rsquo;t change, either the best BD professionals will start competing shops to Locust Walk Partners or they will leave the industry entirely where their skills will be more highly valued (like in banking).</p>
<p>This was not mean to be a white paper in favor of Locust Walk but rather to illustrate a point that CEOs and VCs might not have the right mix on how to extract the maximum value from their important business development professionals.&nbsp; Let&rsquo;s see if they can figure it out!</p>]]></content></entry><entry><title>Negotiate the Exit Before the Entry – Part 3</title><category term="new venture model"/><category term="pre-negotiate exit"/><id>http://blog.locustwalkpartners.com/frontpage/2010/2/27/negotiate-the-exit-before-the-entry-part-3.html</id><link rel="alternate" type="text/html" href="http://blog.locustwalkpartners.com/frontpage/2010/2/27/negotiate-the-exit-before-the-entry-part-3.html"/><author><name>Geoff Meyerson</name></author><published>2010-02-27T05:11:47Z</published><updated>2010-02-27T05:11:47Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>Today I listened to a very interesting, albeit brief, discussion about pre-negotiating the exit before the initial investment at the Venture Panel at the 2010 <a href="http://www.whcbc.org/">Wharton Health Care Business Conference</a>.&nbsp; The moderator asked about structured transactions where the upside is capped by way of an option with a pharma company to purchase the asset/company after a predetermined milestone.&nbsp; The panelists were almost all bullish on this idea with some suggesting that they employ this with great frequency.&nbsp; While I&rsquo;m not surprised, I do think it has become much more acceptable than before given the continued poor exit environment.</p>
<p>Brenda Gavin, Partner at Quaker BioVentures, mentioned that there were only 20 M&amp;A exits in 2009 from venture backed companies that would constitute a good return.&nbsp; She mentioned that there are 3,400 biotechs, all of whom are for sale at any given point.&nbsp; The exit ratio therefore isn&rsquo;t so good, especially with effectively no IPOs taking place.&nbsp; As such, if a VC can pre-negotiate a &ldquo;4x&rdquo; as she mentioned, she would take that any day over an uncertain 10x.</p>
<p>Steven St. Peter from MPM commented on the MPM/Novartis strategic fund as well as other non-disclosed deals of a similar option nature with other pharma companies.&nbsp; He said their fund was doing these deals since 1996, but it wasn&rsquo;t formalized until 2006 with Novartis.&nbsp; His interesting insight is that there is a real range of exit values for biotech M&amp;A.&nbsp; Given the amount that generally needs to be invested to get there, there already is an effective cap on returns.&nbsp; There might be one outlier per year but you can&rsquo;t set-up your fund expecting outliers.&nbsp; Given the effective cap on M&amp;A returns, why not cap your return earlier to derisk the exit?&nbsp; This makes perfect sense to me and something that was mentioned in this blog <a href="../../frontpage/2009/9/17/negotiate-the-exit-before-the-entry.html">half a year ago</a>.</p>
<p>Pharma companies rely on biotechs for a supply of innovative assets to fill their pipeline.&nbsp; They need the VCs to make these risky investments to fund the early stage development. &nbsp;More companies will be asked by their board to find a partner prior to the next round of financing both to derisk the round as well as provide validation.&nbsp; This type of pre-negotiated exit arrangement I predict will become even more common going forward as VCs try to improve their returns.</p>]]></content></entry><entry><title>Locust Walk Partners - 2009 Wrap-up</title><category term="annual highlights"/><category term="fiercebiotech webinar"/><category term="first year review"/><id>http://blog.locustwalkpartners.com/frontpage/2009/12/31/locust-walk-partners-2009-wrap-up.html</id><link rel="alternate" type="text/html" href="http://blog.locustwalkpartners.com/frontpage/2009/12/31/locust-walk-partners-2009-wrap-up.html"/><author><name>Jay Mohr</name></author><published>2010-01-01T01:10:34Z</published><updated>2010-01-01T01:10:34Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>The Locust Walk Partners team is thrilled to have just completed our first year in business.&nbsp; While it was a turbulent time for the industry, we are proud of this year's accomplishments including:</p>
<ul>
<li>Executing nearly 15 client business development, strategic, and commercial advisory engagements, several of which remain in active partnering dialogue</li>
<li>Building a world-class team of transaction, commercial, clinical and technical advisors</li>
<li>Celebrating Jay Mohr's professional milestones with Gloucester Pharmaceuticals' FDA approval of Istodax and its recent <a href="http://ir.celgene.com/phoenix.zhtml?c=111960&amp;p=irol-newsArticle&amp;ID=1362847&amp;highlight=">sale to Celgene for $640M</a>.&nbsp; Jay was the founding CEO where he in-licensed Istodax from Fujisawa, assembled the initial management team, and raised $32M in venture capital.</li>
<li>Geoff Meyerson's first venture investment, Algeta, securing an <a href="http://www.algeta.com/xml_press_underside.asp?xml=http://cws.huginonline.com/A/134655/PR/200909/1339217.xml&amp;menuID=4447&amp;smenuID=7621&amp;ssmenuID=">$800M partnership with Bayer</a> leading to a 6x return on investment.</li>
<li>Participating in several opinion-leading conferences, including FierceBiotech Pharma Partnering Webinar with Ad Rawcliffe (SVP WWBD GSK) and Anna Protopapas (SVP CD Millenium).</li>
</ul>
<p>As follpw-up to the webinar, enclosed is a <a href="http://www.locustwalkpartners.com/files/FierceBiotech%20Webinar%20-%20Fact%20Sheet.pdf">two-page overview</a> on the results of our buy-side survey that we presented on what helps get a deal done. Feel free to pass this on to colleagues and let us know if you would like a copy of the full presentation.</p>
<p>All the best for a Happy Holiday and prosperous New Year!</p>]]></content></entry><entry><title>Follow-up from FierceBiotech Webinar</title><category term="fiercebiotech webinar"/><category term="how to get a deal"/><category term="management team engagement"/><category term="pharma partnering"/><id>http://blog.locustwalkpartners.com/frontpage/2009/10/27/follow-up-from-fiercebiotech-webinar.html</id><link rel="alternate" type="text/html" href="http://blog.locustwalkpartners.com/frontpage/2009/10/27/follow-up-from-fiercebiotech-webinar.html"/><author><name>Geoff Meyerson</name></author><published>2009-10-28T03:40:15Z</published><updated>2009-10-28T03:40:15Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>Today we revealed the results of our buy-side BD survey about licensing best practices at the FierceBiotech Webinar titled "Partnering with Pharma: How to Get a Deal".&nbsp; On the panel with us were Ad Rawcliffe from GSK and Anna Protopapas from Millennium/Takeda.&nbsp; One major takeaway from Ad and Anna's presentation was the need for a strong relationship between the licensors and pharma/biotech partners.&nbsp; Clearly this is more important for a partnership than it is for an outlicense or an M&amp;A.&nbsp; We could not agree more with this sentiment.&nbsp; The problem is that it's very hard and time consuming to establish a relationship with every partner who expresses an interest.&nbsp; Something that most biotech companies don't fully appreciate is the need for the entire senior managemet team to get engaged with partnering discussions, not just the CBO/BD team.&nbsp; While BD at a small company does more than simply facilitate, they need to make sure that they get their team fully engaged to make a deal work.&nbsp; Ultimately you need a clinician or scientist speaking with the partner's clinical champion to get them excited, not a business bozo.&nbsp; For more musing or to get a copy of a six slide overview of the presentation that Jay and I shared, please send me an email at geoff@locustwalkpartners.com.</p>]]></content></entry><entry><title>Negotiate the Exit Before the Entry – Part 2</title><category term="exit strategy"/><category term="new venture model"/><category term="novel pharma partnership"/><category term="venture fund idea"/><id>http://blog.locustwalkpartners.com/frontpage/2009/10/19/negotiate-the-exit-before-the-entry-part-2.html</id><link rel="alternate" type="text/html" href="http://blog.locustwalkpartners.com/frontpage/2009/10/19/negotiate-the-exit-before-the-entry-part-2.html"/><author><name>Geoff Meyerson</name></author><published>2009-10-19T14:17:13Z</published><updated>2009-10-19T14:17:13Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>I had a very interesting conversation on Friday with a business development executive from a major pharmaceutical company (both shall go unnamed to protect confidentiality).&nbsp; He had read my posting about negotiating the exit before the entry and was very intrigued. He told me that his company had started exploring this idea several months ago.&nbsp; They were very attracted to the idea of getting a quality asset without having to pay venture homerun-like returns for the product.&nbsp; Unfortunately the VCs that were approached were not interested.</p>
<p>If entrepreneurs would be willing to cap their upside (albeit with downstream economics that can improve the final number) and pharma companies are interested in making this type of commitment, there has to be a way to attract funding.&nbsp; What investors in this market wouldn&rsquo;t want a completely uncorrelated 2-3x return with potential longer term upside?&nbsp; My guess is that eventually the VC community will stubbornly come around and invest at least part of their portfolio with this concept.</p>
<p>The other answer is to start a fund whereby the top 5 pharma companies all agree to share these deals with a pre-negotiated exit with the new fund.&nbsp; The entire remit of the fund would be to fund these companies.&nbsp; While the upside for each individual investment might not be gigantic, the downside theoretically is much less given it has gone through &ldquo;pharma diligence&rdquo; rather than &ldquo;VC diligence&rdquo; which is arguably much more thorough and has a much higher success rate.&nbsp; Anyone willing to give me $300M to make this happen?</p>]]></content></entry><entry><title>Business Development Course @ Wharton</title><category term="business development"/><category term="wharton"/><id>http://blog.locustwalkpartners.com/frontpage/2009/10/12/business-development-course-wharton.html</id><link rel="alternate" type="text/html" href="http://blog.locustwalkpartners.com/frontpage/2009/10/12/business-development-course-wharton.html"/><author><name>Geoff Meyerson</name></author><published>2009-10-12T13:16:00Z</published><updated>2009-10-12T13:16:00Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>Jay and I taught a business development class at Wharton this past week as part of the Healthcare Finance class (HCMG 849).&nbsp; We spoke mostly about the process of buying and selling assets combining this with financial analysis modeling to correlate terms in a term sheet with the financial impact of them.</p>
<p>Since this was well received, we plan to make this into a day-long course testing it again with the Wharton students.&nbsp; Our hope is to eventually make this course more broadly available in conjunction with either an eBook or published book on business development.&nbsp; If you&rsquo;re curious to see the presentation that we gave, we&rsquo;ll be posting it on this blog shortly.&nbsp; Email <a href="mailto:geoff@locustwalkpartners.com">Geoff</a> if you&rsquo;d like a copy.&nbsp; If you have suggested topics for this eBook/book, please let me know.</p>]]></content></entry><entry><title>Thought Leadership at Locust Walk Partners</title><id>http://blog.locustwalkpartners.com/frontpage/2009/10/11/thought-leadership-at-locust-walk-partners.html</id><link rel="alternate" type="text/html" href="http://blog.locustwalkpartners.com/frontpage/2009/10/11/thought-leadership-at-locust-walk-partners.html"/><author><name>Geoff Meyerson</name></author><published>2009-10-12T02:03:33Z</published><updated>2009-10-12T02:03:33Z</updated><summary type="html" xml:lang="en-US"><![CDATA[Thur Oct 01, 2009 9:30am EDT
BOSTON, MA and PHILADELPHIA, PA--(Marketwire - October 1, 2009) - Locust Walk Partners (LWP), a business development advisory firm for life science companies, announced today that its founding partners will be speaking at three leading industry events this month. The firm has also started a blog to discuss emerging trends in business development.

The LWP team will speak at the following venues:

      -- Jay Mohr and Geoff Meyerson will be panelists in FierceBiotech's webinar "How to Land a Deal: Partnering with Big Pharma," which takes place October 27, 2009 at 2pm EDT. Joining LWP are John Carroll, FierceBiotech Editor; Anna Protopapas, SVP, Corporate Development, Millennium Takeda; and Ad Rawcliffe, SVP, Worldwide Business Development and R&D Finance, GlaxoSmithKline.

      -- Jay Mohr, Managing Director, will speak on a panel at the Licensing Executive Society Annual Meeting, entitled "Non-dilutive and Other Non-traditional Forms of Financing." The panel takes place at 2:00pm PDT on October 21, 2009 at the San Francisco Marriott in San Francisco, CA.

      -- Geoff Meyerson, Managing Director, will speak on a panel at the Financing Solutions & Strategies for Life Sciences Conference at 9:15am EDT on October 20th, 2009 at The Carlton in New York, NY.

LWP is also launching a business development blog providing insights into the thoughts, interactions, and analysis of the team. "We are excited to use a modern communications forum for an industry that has been slow to adopt web technology. Hopefully our industry colleagues will find this free content useful, will engage with us in meaningful dialog, and will share it with friends," said Geoff Meyerson.

The new blog is at: http://blog.locustwalkpartners.com. If you are interested in receiving updates from our blog as well as other upcoming LWP thought leadership activities and articles, please sign up for the RSS feed.]]></summary></entry><entry><title>Negotiate the Exit before the Entry</title><category term="dual track process"/><category term="exit strategy"/><category term="fundraising strategy"/><category term="new venture model"/><id>http://blog.locustwalkpartners.com/frontpage/2009/9/17/negotiate-the-exit-before-the-entry.html</id><link rel="alternate" type="text/html" href="http://blog.locustwalkpartners.com/frontpage/2009/9/17/negotiate-the-exit-before-the-entry.html"/><author><name>Geoff Meyerson</name></author><published>2009-09-17T04:16:00Z</published><updated>2009-09-17T04:16:00Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p><span>
<div style="text-align: justify;"><span class="Apple-style-span" style="  ;font-family:verdana, serif;font-size:small;">Jay and I recently had a nice chat with a prominent entrepreneur.  He has worked on many successful startups that raised a lot of venture capital money and eventually went public and/or sold.  His current start-up is having a bit more difficulty than his previous companies getting off the ground.  (If someone of this stature is having trouble raising money, I can only imagine the first time CEO with an early stage product trying to raise capital.  Ouch!).  He mentioned to us an idea for a new strategy to concurrently raise VC money and look to partner the asset, not sell the company.  In times past, this idea was asinine.  I think it makes perfect sense and is something I was discussing with other colleagues several months back.  Maybe there is something here.</span></div>
</span></p>
<div style="text-align: justify;"><span class="Apple-style-span" style="font-family:verdana;"><span class="Apple-style-span" style="font-size:small;"><br /></span></span></div>
<div style="text-align: justify;"><span><span><span class="Apple-style-span" style="font-family:verdana;"><span class="Apple-style-span" style="font-size:small;">The idea isn&rsquo;t as crazy, in my mind at least, as once thought.  You used to be able to fund a company, develop to phase 2a proof-of-concept and sell for $250-400M for a 3-5x return.  With acquisition values going down and taking more of a licensing feel with deferred milestones, the returns are simply not there for VCs.  Because exits are harder to come by, I would argue that you need to de-risk this previously less-risky aspect of venture investing.  Remember that in biotech, VCs generally take technical risk, not market risk like their tech VC cousins.  Getting good phase 2a data is no longer a guarantee of financial success and thus you need to lower the risk profile of these investments.  The only way to lower the risk profile without somehow reducing technical risk is to reduce market risk.  In this case, market risk is really exit risk.  I think you should pre-sell the exit.</span></span></span></span></div>
<div style="text-align: justify;"><span class="Apple-style-span" style="font-family:verdana, serif;"><span class="Apple-style-span" style="font-size:small;"><br /></span></span></div>
<div style="text-align: justify;"><span><span><span class="Apple-style-span" style="font-family:verdana;"><span class="Apple-style-span" style="font-size:small;">If you negotiate a license or M&amp;A deal before committing significant additional capital, you cap your upside but can guarantee a 2-3x if your company is willing to take the clinical and execution risk.  While this strategy might not be widely adopted now, I think that pharma companies will increasingly partner with VCs to lock down assets more cheaply and earlier, while still taking getting the R&amp;D spend off of their P&amp;L.  As I mentioned previously on this blog, a license can be a form of an exit so this can enable you to still not cap your upside if you take royalties and commercial milestones into account.</span></span></span></span></div>
<div style="text-align: justify;"><span class="Apple-style-span" style="font-family:verdana, serif;"><span class="Apple-style-span" style="font-size:small;"><br /></span></span></div>
<div style="text-align: justify;"><span><span><span class="Apple-style-span" style="font-family:verdana;"><span class="Apple-style-span" style="font-size:small;">VCs won&rsquo;t want to do this for every company in their portfolio.  However, to have a &ldquo;guaranteed&rdquo; return for a few companies in a portfolio to take out the exit risk, I&rsquo;d sure take a hard look at that strategy.</span></span></span></span>
<p class="MsoNormal" style="text-align:justify">&nbsp;</p>
</div>
<p>&nbsp;</p>]]></content></entry><entry><title>BioPharma Licensing in 2009: Staying Above the Noise</title><category term="above the noise"/><category term="biopharma licensing"/><category term="business development"/><category term="commercial story"/><category term="differentiation"/><category term="licensing"/><id>http://blog.locustwalkpartners.com/frontpage/2009/9/8/biopharma-licensing-in-2009-staying-above-the-noise.html</id><link rel="alternate" type="text/html" href="http://blog.locustwalkpartners.com/frontpage/2009/9/8/biopharma-licensing-in-2009-staying-above-the-noise.html"/><author><name>Jay Mohr</name></author><published>2009-09-08T17:31:00Z</published><updated>2009-09-08T17:31:00Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p class="MsoNormal" style="TEXT-ALIGN: justify"><span class="Apple-style-span" style="font-size:small;">We&rsquo;ve recently posted on this Blog that licensing transactions appear to be overtaking biotech mergers and acquisitions as the means for investors and management teams to exit and realize value from their companies. Proceeds from backup assets and earlier pipeline candidates are the fuel to keep companies alive to drive lead programs.</span></p>
<p class="MsoNormal" style="TEXT-ALIGN: justify"><span class="Apple-style-span" style="font-size:small;">The licensing environment in 2009 is clearly a &ldquo;buyer&rsquo;s market&rdquo;. Pharmaceutical business development professionals are being bombarded by biotechnology firms with offers to license or acquire programs. The noise level in the market is unprecedented. For biotech firms, this means that preparation for a licensing effort is more important than ever.</span></p>
<p class="MsoNormal" style="TEXT-ALIGN: justify"><span class="Apple-style-span" style="font-size:small;"><strong>Evidence of Differentiation</strong>. In a competitive licensing environment, strong indications of differentiation are perhaps the most important factor in gaining a partner&rsquo;s attention. Ideally, this would include randomized Phase 2 data versus standard of care. If resources are constrained, a validated, well-controlled pre-clinical model, can help strengthen the marketing package.</span></p>
<p class="MsoNormal" style="TEXT-ALIGN: justify"><span class="Apple-style-span" style="font-size:small;"><strong>Sound Commercial Story</strong>. Telling the buyer it&rsquo;s a $1 billion opportunity will gain little attraction. A licensor&rsquo;s successful commercial case should include: 1) A solid understanding of the market conditions and trends and competitive landscape now, at launch and 5 years post-launch. This can be based on secondary data sources; 2) A target product profile (TPP) whose claims are justified by pre/clinical data, including active comparators; 3) Market feedback on the TPP from key opinion leaders (KOLs) in the relevant therapeutic area; and 4) a high level assessment of the commercial potential based on the previous factors. A $650 million opportunity that considers reality will gain more credibility than the &ldquo;unsupported blockbuster&rdquo;.</span></p>
<p class="MsoNormal" style="TEXT-ALIGN: justify"><span class="Apple-style-span" style="font-size:small;"><strong>Getting to the Champions</strong>. This is a factor which often is mentioned but difficult to achieve. Depending on the development stage of the asset, any number of functions can be the internal champion for the licensor: Research, Clinical, Commercial and Senior Management. In licensing team, these groups weigh heavy on types/classes assets that are of most interest, due diligence go/no go factors, and deal terms that are deal breakers. Licensees&rsquo; Business Development are essential for completing a smooth process and maintaining opening communication, but it is rare that these individuals will serve as champions.</span></p>
<p class="MsoNormal" style="TEXT-ALIGN: justify"><span class="Apple-style-span" style="font-size:small;"><strong>Willingness to be Creative</strong>. Deal terms have traditionally been the bellweather of measuring / validating the value that&rsquo;s been created by the licensor - &ldquo;more is better&rdquo;. Even with a compelling asset, big bio/pharma licensees are increasingly P&amp;L sensitive and seemingly taking a wait and see approach. This situation has led to a wide range of non-traditional structures, the range and impact of which should be considered before initiating a licensing process. Creative scenarios might include option-based deals with R&amp;D funding; co-funding by a partner&rsquo;s venture capital arm, etc.</span></p>]]></content></entry><entry><title>The Venture Investing Strategy for Tough Times</title><category term="investing"/><category term="recession"/><category term="start-up"/><category term="strategy"/><category term="venture capital"/><id>http://blog.locustwalkpartners.com/frontpage/2009/8/27/the-venture-investing-strategy-for-tough-times.html</id><link rel="alternate" type="text/html" href="http://blog.locustwalkpartners.com/frontpage/2009/8/27/the-venture-investing-strategy-for-tough-times.html"/><author><name>Geoff Meyerson</name></author><published>2009-08-27T04:31:00Z</published><updated>2009-08-27T04:31:00Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p class="MsoNormal" style="text-align: justify;"><span class="Apple-style-span" style="font-size: small;">I had an interesting conversation yesterday with a good buddy of mine who works at a top venture capital firm.  I mentioned that Locust Walk Partners is considering doing company formation work.  I wanted to know if he thought that we were crazy.  He responded that he actually is spending a lot of time these days on company formation.  During the conversation he also discussed why they decided not to make a follow-on investment in a company, and that they were subsequently converted to common.  He also talked about completely dysfunctional boards and syndicates that cannot agree on anything, and as such companies make poor choices.  How does this all fit together?</span></p>
<p class="MsoNormal" style="text-align: justify;"><span class="Apple-style-span" style="font-size: small;">Follow-on investments in current portfolio companies might be throwing good money after bad (note: not all follow-ons are a waste of money and winners should be continued).  The valuations of most current portfolio companies funded more than a year ago are overvalued given this environment.  Short of recapping the company, insider rounds are only going to make the problem worse by increasing the valuation, generally at a flat price.  Bruce Booth at Atlas Venture eloquently demonstrated in a Nature Biotech article that the intuitively obvious observation that more money invested and thus higher valuations leads to lower returns.  LWP is about to unveil an analysis that says that much of the funding these days in existing companies, not surprisingly is insider rounds.  Getting a deal done today with an external investor is extremely difficult for a host of reasons.  Many of these outside investor deals where the new investor prices the round need to be done at a down valuation.  There clearly are political implications of doing this.  So, what is the answer?</span></p>
<p class="MsoNormal" style="text-align: justify;"><span class="Apple-style-span" style="font-size: small;">Company formation is the only way to control the valuation, get founders shares in addition to preferred stock, control over the selection of the management team, control the venture syndicate and dictate the terms for the Series A round.  While some venture funds have been successfully doing this for a while, others don&rsquo;t think it is worth their time.  I postulate that in this venture market, VCs should be working on funding more new companies with innovative technologies, not mee-too retreads further in development.  Maybe VCs should even consider reallocating to start-ups some of the recently increased allocation they &ldquo;reserve&rdquo; for current portfolio companies.  A recent webinar given by ReCap stated that they think that the shift among buyers (big pharma/biotech) will be from the late stage, which are very picked over, to collaborations earlier in the development cycle, including research and pre-clinical stage.  Sounds to me like a great opportunity worth pursuing!</span></p>]]></content></entry></feed>